Valerian is a flowering plant native to Europe and Asia, whose use dates back to ancient Greek and Roman civilizations.
✓ Promote calm
✓ Improve sleep quality
✓ Support relaxation
How it works:
Valerian root is the most commonly used botanical to promote healthy sleep in the United States and Europe. The root of the plant has been shown to contain both gamma-aminobutyric acid (GABA) and bioactive compounds such as valerenic acid, which shows GABAergic activity. GABA is a neurotransmitter produced naturally in the body that is responsible for relaying messages through the brain and central nervous system to promote calm, relaxation, and healthy sleep without undesirable morning effects.
Safe and Effective Dosage:
Clinical studies support safe, effective dosages between 100 mg to 600 mg per day with our optimal dosage on the lower end of the range due to synergistic behavior with 5-HTP from Griffonia simplicifolia and Passion Flower.
RESEARCH &CLINICAL STUDIES
"The roles of valerenic acid on BDNF expression in the SH-SY5Y cell"
The roots of Valeriana officinalis L. (Valerianaceae) are used for treating sleep disorders and/or mild nerve tension.
The effect of valerenic acid on brain-derived neurotrophic factor (BDNF) has not yet been studied, although it is known that gamma-amino butyric acid A (GABAA) receptor is regulated by BDNF, which modulates the depressive-like behavior and neurogenesis.
The purpose of this study is to determine the effect of V. officinalis root extract (VO), its main constituents valerenic acid (VA) and acetoxy valerenic acid (AVA) as well as valerenic acid-free (VAF), acetoxy valerenic acid-free (AVAF) extracts and increasing amounts of valerenic acid containing extracts on the BDNF expression in SH-SY5Y cell lines.
The effect of methanolic extracts of VO, VA, AVA, VAF, AVAF, and the extracts whose amount of VA were increased gradually, were tested using a Human BDNF ELISA kit with 17β-estradiol as a positive control. The VO and VA extracts caused a significant (p < 0.001) increase in the BDNF expression in SH-SY5Y cells compared to control. This effect completely disappeared when cells were treated with VAF extract. AVA alone did not show any significant change in the BDNF levels. The extracts with increasing amount of VA led to a concentration- dependent effect on the cells.
In conclusion, our findings suggest that the antidepressant-like effect of the VO extract is also related to BDNF expression, and that this is mainly due to the presence of VA in the extract. Removing VA from VO extract leads to a loss of activity.
Moreover, the concentration of VA plays a role for BDNF expressions in SH-SY5Y cells, which demonstrates the importance of quality control on the commercially available products.
"Valerian for Sleep: A Systematic Review and Meta-Analysis"
Insomnia affects approximately one-third of the adult population and contributes to increased rates of absenteeism, health care use, and social disability.
Extracts of the roots of valerian (Valeriana officinalis) are widely used for inducing sleep and improving sleep quality. A systematic review of randomized, placebo-controlled trials of valerian for improving sleep quality is presented.
An extensive literature search identified 16 eligible studies examining a total of 1093 patients. Most studies had significant methodologic problems, and the valerian doses, preparations, and length of treatment varied considerably.
A dichotomous outcome of sleep quality (improved or not) was reported by 6 studies and showed a statistically significant benefit (relative risk of improved sleep = 1.8, 95% confidence interval, 1.2-2.9), but there was evidence of publication bias in this summary measure.
The available evidence suggests that valerian might improve sleep quality without producing side effects. Future studies should assess a range of doses of standardized preparations of valerian and include standard measures of sleep quality and safety.