Horsetail is a natural perennial plant that contains a wide variety of bioactive compounds known to support skin health, such as phytosterols, tannins, flavonoids, triterpenoids, and Vitamin C. Horsetail also contains a unique, natural form of silicon called salicylic acid. Silicon is essential for producing collagen, and for the activation of enzymes within the collagen matrix, which have been shown to support both skin strength and elasticity.

Citrus Bioflavonoids complexes are naturally extracted from the rinds and peels of citrus fruits and contain Vitamin C, as well as a wide range of flavonoids, including quercetin, hesperidin, and rutin. Bioflavonoids have synergistic relationships with Vitamin C, and in its presence, flavonoids such as quercetin, have been shown to help repair oxidative damage and promote neurovascular structure in the skin, which aids in cell regeneration and hydration. Flavonoids and polyphenols also fight harmful free radicals and inhibit advanced glycation end product (AGE) formation, which supports longevity and cognition. Studies have also shown that another important bioflavonoid, hesperidin, promotes tone/texture improvements and radiance by downregulating matrix metalloproteinase (MMP) expression that is responsible for wrinkles due to photoaging or chronic sunlight (UV) exposure. Other studies have shown that flavonoids, such as quercetin and rutin, can replenish aging cells, promoting elasticity and longevity of healthy skin.

Lutein is a xanthophyll, or naturally occurring carotenoid, found in high quantities in the Marigold Flower. Lutein is responsible for protection against UV induced damage caused by sunlight. Recent clinical studies have demonstrated that lutein is able to block melanin pathways, down regulate cytokines, and promote antioxidants, which promotes tone/texture improvements and improves skin appearance.

Griffonia simplicifolia, is a shrub whose seeds contain a high concentration of 5-hydroxytryptophan, otherwise known as 5-HTP. As a precursor to serotonin, 5-HTP increases serotonin, which triggers receptors in the central nervous system that modulate and support sleep and mood. Research has shown that serotonin is essential for body clock functions, regulation of sleep-wake behaviour, and helps promote calm and restful sleep.

Valerian root has been shown to contain both gamma-aminobutyric acid (GABA) and bioactive compounds such as valerenic acid, which shows GABAergic activity. GABA is a neurotransmitter, produced naturally in the body, that is responsible for relaying messages through the brain and central nervous system to promote calm, relaxation, and healthy sleep without undesirable morning effects.

Historical usage of passion flower dates back to Native Americans and the Aztecs, as well as modern cultures, with the primary use related to promoting calm and sleep. The flower of this plant contains a vast array of bioactive compounds such flavonoids, glycosides, and amino acids, including GABA. It is synergistic with both Griffonia simplicifolia and Valerian Root due to its role in GABAergic activity. Research also supports its use to promote quality of life for restlessness and stress.

Recent research has shown beneficial results of lavender flower used both orally and topically to promote healthy aging of skin and body through interactions with prostanoids, proinflammatory cytokines, and histamine pathways. Clinical research supports the use of lavender to promote natural, healthy stress response, sleep quality, and relaxation.

Hops contains oil terpenoids such as mycerne, beta-caroypophylene, and a complex mixture of flavonoids and polyphenols, which benefit skin health. Hops have long been used with valerian root and have a synergistic relationship to promote mood and support healthy stress response. Recent research has also shown that natural terpenoids help maintain healthy cholesterol levels and scavenge harmful hydroxyl free radicals, essential to healthy aging and longevity.

Japanese Knotweed is popular in both historical and modern use for its high natural abundance of trans-resveratrol; a natural phenol well studied for its support of cardiovascular health, skin health, longevity, and healthy aging. Studies have shown that resveratrol targets active sites in epidermal cells, and can upregulate compounds within the body (i.e. glutathione peroxidase) that protect against oxidative related skin damage during aging.