Polypodium leucotomos is a fern native to tropical regions of North and South America. Traditionally used by the Native Americans, recent research indicates that it protects keratinocytes, which represent 90% of the cells in the epidermis or outer layer of the skin.


Support radiance
UV protective properties
Aid in cellular regeneration
Support cell repair
Repair oxidative damage
Aid in protecting DNA

How it works:

How it works: The plant contains a high abundance of glycosides that have demonstrated UV protective effects that help repair oxidative damage to the skin caused by sunlight exposure, supporting healthy cellular regeneration and radiance. Research has also shown potential induction of p53 proteins responsible for protecting DNA.

Safe and Effective Dosage:

Research supports safe and effective dosages between 120-1080 mg per day.

Our dosage:

200 mg





"Safety and Efficacy of Oral Polypodium leucotomos Extract in Healthy Adult Subjects"


Objective: The objective of this study was to determine the safety of oral Polypodium leucotomos extract administered twice daily to healthy adults for 60 days and assess its ability to provide protection against exposure to ultraviolet radiation.

Design: This was a randomized, double-blind, placebo-controlled study.

Setting: A single clinical research center.

Participants: Healthy adult men and women between 18 and 65 years of age with Fitzpatrick skin types I to IV.

Measurements: Safety assessments included a physical examination, vital signs, and clinical laboratory parameters including hematology, comprehensive metabolic panel, and prothrombin time-partial thromboplastin time were obtained at baseline and at the end of the study. Reports of adverse events were recorded. Efficacy assessments were changes in minimal erythema dose testing, ultraviolet-induced erythema intensity response, and sunburn history during the prior 60 days.

Results: After two months of treatment, there were no changes in any safety assessments. The subjects in the placebo group showed a greater likelihood of experiencing >1 episodes of sunburn (2 vs. 8 subjects; p=0.04) At Day 28, Polypodium leucotomos extract-treated subjects showed greater likelihood of an increased minimal erythema dose (8 vs. 1 subject; p=0.01) and greater likelihood of decreased ultraviolet-induced erythema intensity (10 subjects vs. 3 subjects; p<0.01).

Conclusion: Polypodium leucotomos extract 240mg taken twice daily for 60 days was a safe and effective means for reducing the damaging effects of ultraviolet radiation. Based on the excellent safety profile of Polypodium leucotomos, additional studies using higher doses may be warranted.

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"Polypodium leucotomos extract: a status report on clinical efficacy and safety"


Various extracts of polypodium leucotomos (PLE) applied topically or taken orally have been shown to have several beneficial antioxidant, photoprotectant, antimutagenic, and immunoregulatory effects.

Modern studies have evaluated the efficacy of PLE orally as a photoprotective agent and for use in several photo-aggravated dermatologic disorders such as polymorphous light eruption, other photodermatoses, and melasma.

No articles have been published evaluating the safety of PLE. We performed a PUBMED search for any randomized clinical trials related to PLE, or anapsos, a synonym.

The primary safety endpoint of the review was any mention of an adverse event, side effect, or toxicity.

Overall, 19 human and 6 basic science studies were included spanning over 40 years of research. Oral PLE was administered at daily doses ranging from 120 mg to 1080 mg. No adverse effects were reported in laboratory studies. In humans, side effects (gastrointestinal complaints and pruritus) were mild to moderate and found only in very small numbers of patients overall (16/1016 [2%]).

This review concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.

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