Passion Flower is a perennial climbing vine, native to tropical regions of North, Central, and Southern America. Historical usage of the plant dates back to Native Americans and the Aztecs, as well as modern cultures, with the primary use related to calming and promoting sleep.
✓ Promote calm
✓ Improve sleep quality
✓ Support relaxation
How it works:
The flower of this plant contains a vast array of bioactive compounds such as flavonoids, glycosides, and amino acids, including GABA. Synergistic with both Griffonia simplicifolia and Valerian Root due to its role in GABAergic activity, research also supports its use to promote quality of life for restlessness and stress.
Safe and Effective Dosage:
Clinical studies support safe, effective dosages between 50 mg to over 700 mg per day, with our optimal dosage on the lower end of the range due to synergistic behavior with 5-HTP from Griffonia simplicifolia and Valerian Root.
RESEARCH &CLINICAL STUDIES
"Passionflower in the treatment of generalized anxiety: a pilot double‐blind randomized controlled trial with oxazepam"
Objective: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double‐blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder.
Methods: The study was performed on 36 out‐patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam 30 mg/day plus placebo drops for a 4‐week trial.
Results: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam.
Conclusion: The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage. A large‐scale trial is justified.
"[Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passion Flower Dry Extract]"
Background: The passion flower dried ethanolic extract investigated in this non-interventional study has well-documented calmative effects and good tolerability. We investigated the effects of this extract on the stress resistance (resilience) and quality of life (QoL) of patients suffering from nervous restlessness. The addiction potential of the drug and the course of symptoms were also evaluated.
Methods: Adult patients aged ≤ 95 years with the diagnosis ‘nervous restlessness’ were treated for 12 weeks with a dried ethanolic extract of passion flower (Passiflora incarnata L.). Standardized questionnaires were used to evaluate the resilience (RS-13), QoL (EQ-5D including EQ-VAS), and the addiction potential (BDEPQ).
Results: After 12 weeks of treatment, significant (p < 0.001) improvements were measured in the patients’ resilience (RS-13: from 52.1 to 67.7 points) and QoL (EQ-VAS: from 47.9 to 75.0 points). Also, the mean BDEPQ score was significantly (p < 0.001) reduced (from 23.0 to 19.3 points). The mean values of all accompanying symptoms (inner restlessness, sleep disturbance, exhaustion, fear, lack of concentration, transpiration, nausea, trembling, and palpitation) improved significantly (p < 0.001). Tolerability of treatment was rated as ‘very good’ or ‘good’ by the majority of the patients. Three cases of mild adverse events (tiredness) were reported.
Conclusion: The passion flower extract investigated in the present study appears to be effective in improving resilience and QoL in patients suffering from nervous restlessness and is well tolerated.