From Tomato Extract
Lycopene is a natural carotenoid found in vegetables and fruit, and is present in high amounts in tomatoes.
✓ Support radiance
✓ Improve hydration
✓ UV protective benefits
How it works:
Studied extensively for over 70 years, lycopene has numerous health benefits, and like other carotenoids, is a powerful antioxidant and UV absorber. The compound also increases production of other carotenoids, such as beta-carotene. Carotenoids such as lycopene and beta-carotene are found in abundance in the skin and have photoprotective properties that protect cells from harmful UV radiation while supporting both radiance and hydration.
Safe and Effective Dosage:
Clinical studies support safe dosages from 7 mg to over 75 mg per day, although recent research on bioavailability suggests the optimum dosage is 10 mg per day.
RESEARCH &CLINICAL STUDIES
"An Update on the Health Effects of Tomato Lycopene"
Lycopene is a non-provitamin A carotenoid that is responsible for the red to pink colors seen in tomatoes, pink grapefruit, and other foods.
Processed tomato products are the primary dietary lycopene source in the United States. Unlike many other natural compounds, lycopene is generally stable to processing when present in the plant tissue matrix.
Recently, lycopene has also been studied in relation to its potential health effects.
Although promising data from epidemiological, as well as cell culture and animal, studies suggest that lycopene and the consumption of lycopene containing foods may affect cancer or cardiovascular disease risk, more clinical trial data is needed to support this hypothesis.
In addition, future studies are required to understand the mechanism(s) whereby lycopene or its metabolites are proven to possess biological activity in humans.
"A physiological pharmacokinetic model describing the disposition of lycopene in healthy men"
A physiological pharmacokinetic model was developed to describe the disposition of lycopene, delivered as a tomato beverage formulation in five graded doses (10, 30, 60, 90, or 120 mg), for a phase I study in healthy male subjects (five per dose).
Blood was collected before dose administration (0 h) and at scheduled intervals until 672 h. Serum concentrations of carotenoids and vitamins were measured by high performance liquid chromatography analysis.
The model was comprised of seven compartments: gastrointestinal tract, enterocytes, chylomicrons, plasma lipoproteins, fast-turnover liver, slow-turnover tissues, and a delay compartment before the enterocytes.
As predicted, the percent absorption at the 10 mg dose (33.9 +/- 8.1%) was significantly greater than at the higher doses; however, the amount of lycopene absorbed (mg) was not statistically different (mean: 4.69 +/- 0.55 mg) between doses, suggesting a possible saturation of absorptive mechanisms. The slow-turnover tissue compartment served as a slow-depleting reservoir for lycopene, and the liver represented the fast-turnover pool. Independent of dose, 80% of the subjects absorbed less than 6 mg of lycopene.
This may have important implications for planning clinical trials with pharmacological doses of lycopene in cancer control and prevention if absorption saturation occurs at levels that are already being consumed in the population.