Ultimate pm - 200mg
Valerian is a flowering plant native to Europe and Asia, whose use dates back to ancient Greek and Roman civilizations.
HOW IT WORKS
Valerian root is the most commonly used botanical to promote healthy sleep in the United States and Europe. The root of the plant has been shown to contain both gamma-aminobutyric acid (GABA) and bioactive compounds such as valerenic acid, which shows GABAergic activity. GABA is a neurotransmitter produced naturally in the body that is responsible for relaying messages through the brain and central nervous system to promote calm, relaxation, and healthy sleep without undesirable morning effects.
✓ Promote calm
✓ Improve sleep quality
✓ Support relaxation
✓ Improve cognition
✓ Reduce anxious feeling
✓ Improve mood
RESEARCH &CLINICAL STUDIES
"Valerian for Sleep: A Systematic Review and Meta-Analysis"
A dichotomous outcome of sleep quality (improved or not) was reported by 6 studies and showed a statistically significant benefit (relative risk of improved sleep = 1.8, 95% confidence interval, 1.2-2.9), but there was evidence of publication bias in this summary measure.
"The roles of valerenic acid on BDNF expression in the SH-SY5Y cell"
In conclusion, our findings suggest that the antidepressant-like effect of the VO extract is also related to BDNF expression, and that this is mainly due to the presence of VA in the extract. Removing VA from VO extract leads to a loss of activity.
"Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis"
This study was conducted to update and re-evaluate the available data in order to understand the reason behind the inconsistent outcomes and to provide a broader view of the use of valerian for associated disorders.
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