HORSETAIL EXTRACT

Equisetum Arvense

Horsetail is a natural perennial plant widespread in the northern hemisphere, and native to North America, Russia, Norway, and Sweden.

Benefits:

Collagen production
Strengthen elasticity
Improve skin strength

How it works:

The plant contains a wide variety of bioactive compounds known to support skin health, such as phytosterols, tannins, flavonoids, triterpenoids, and Vitamin C. Horsetail also contains a unique, natural form of silicon called salicylic acid. Silicon is essential for producing collagen and for the activation of enzymes within the collagen matrix that have been shown to support both skin strength and elasticity.

Safe and Effective Dosage:

Clinical studies support safe, effective dosages between 10.5 mg to over 40 mg per day of Silica.

Our dosage:

200 mg. The Horsetail Stem Extract used in STUNN formulations is standardized to 7% Silica, so the formulation contains approximately 14 mg of Silica.

NON-GMO

VEGAN

GLUTEN FREE

RESEARCH &
CLINICAL STUDIES

"Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells"

ABSTRACT:

In Europe, extracts of Equisetum arvense (common horsetail) have a long tradition in the treatment of inflammatory disorders. To understand the molecular basis for its use, we investigated the immunomodulatory capacity of a standardized commercially available common horsetail extract on human primary lymphocyte function in vitro.

Methods: The standardized extract of Equisetum arvense was phytochemically characterized. Effects on proliferation, viability and activity of mitogen-activated human lymphocytes were assessed in comparison to cyclosporine A using annexin V/propidium iodide staining assays and flow cytometry-based surface receptor characterization, respectively. Intracellular levels of effector molecules (IL-2, IFN-γ and TNF-α) were analyzed with cytokine assays.

Results: T cell proliferation was inhibited dose dependently by the Equisetum extract without induction of apoptosis or necrosis. This effect was mediated through inhibition of lymphocyte activation, specifically by diminishing CD69 and IL-2 surface receptor expression and intracellular IL-2 production. Furthermore, treatment with Equisetum arvense inhibited effector functions, as indicated by reduced production of IFN-γ and TNF-α.

Conclusions: The data indicate that the used extract of Equisetum arvense interferes with the polyfunctionality of immunocompetent cells thereby providing an anti-inflammatory mode-of-action.

 

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"Use of silicon for skin and hair care: an approach of chemical forms available and efficacy*"

ABSTRACT:

Silicon is the second most abundant element on Earth, and the third most abundant trace element in human body. It is present in water, plant and animal sources.

On the skin, it is suggested that silicon is important for optimal collagen synthesis and activation of hydroxylating enzymes, improving skin strength and elasticity.

Regarding hair benefits, it was suggested that a higher silicon content in the hair results in a lower rate of hair loss and increased brightness. For these beneficial effects, there is growing interest in scientific studies evaluating the efficacy and safety of using dietary supplements containing silicon.

Its use aims at increasing blood levels of this element and improving the skin and its annexes appearance. There are different forms of silicon supplements available and the most important consideration to be made in order to select the best option is related to safety and bioavailability. Silicon supplements are widely used, though there is wide variation in silicon bioavailability, ranging from values below 1% up to values close to 50%, depending on the chemical form.

Therefore, the aim of this study was to evaluate the scientific literature related to the different chemical forms of silicon supplements available and the limitations and recent progress in this field.

According to reported studies, among the different chemical forms available, the orthosilicic acid (OSA) presents the higher bioavailability, whereas the others forms have absorption inversely proportional to the degree of polymerization.

However, clinical studies evaluating safety and efficacy are still lacking.

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CITRUS BIOFLAVONOIDS

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