Griffonia simplicifolia is a shrub native to Africa, whose seeds contain a high concentration of 5-hydroxytryptophan, otherwise known as 5-HTP.
✓ Naturally increase serotonin
✓ Improve mood
✓ Promote calm
✓ Support quality sleep
How it works:
As a precursor to serotonin, 5-HTP increases serotonin, which triggers receptors in the central nervous system that modulate and support sleep and mood. Research has shown that serotonin is essential for bodyclock functions and regulation of sleep-wake behavior. Intended use is dependent on the time of day that serotonin levels are raised, therefore, 5-HTP is best supplemented in the afternoon to promote calm and a restful sleep. Valerian root, which contains GABA, is also synergistic with 5-HTP.
Safe and Effective Dosage:
Clinical studies support safe, effective dosages between 55 mg to 900 mg per day, with our optimal dosage on the lower end of the range due to synergistic behavior with Valerian Root and Passion Flower.
RESEARCH &CLINICAL STUDIES
"Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis"
The serotonergic system forms a diffuse network within the central nervous system and plays a significant role in the regulation of mood and cognition.
Manipulation of tryptophan levels, acutely or chronically, by depletion or supplementation, is an experimental procedure for modifying peripheral and central serotonin levels.
These studies have allowed us to establish the role of serotonin in higher order brain function in both preclinical and clinical situations and have precipitated the finding that low brain serotonin levels are associated with poor memory and depressed mood.
The gut-brain axis is a bi-directional system between the brain and gastrointestinal tract, linking emotional and cognitive centres of the brain with peripheral functioning of the digestive tract.
An influence of gut microbiota on behaviour is becoming increasingly evident, as is the extension to tryptophan and serotonin, producing a possibility that alterations in the gut may be important in the pathophysiology of human central nervous system disorders.
In this review we will discuss the effect of manipulating tryptophan on mood and cognition, and discuss a possible influence of the gut-brain axis.
"Sleep-promoting effects of a GABA/5-HTP mixture: Behavioral changes and neuromodulation in an invertebrate model"
Aims: This study was to investigate the sleep promoting effects of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP), by examining neuronal processes governing mRNA level alterations, as well as assessing neuromodulator concentrations, in a fruit fly model.
Main methods: Behavioral assays were applied to investigate subjective nighttime activity, sleep episodes, and total duration of subjective nighttime sleep of two amino acids and GABA/5-HTP mixture with caffeine treated flies. Also, real-time PCR and HPLC analysis were applied to analyze the signaling pathway.
Key findings: Subjective nighttime activity and sleep patterns of individual flies significantly decreased with 1% GABA treatment in conjunction with 0.1% 5-HTP treatment (p<0.001). Furthermore, GABA/5-HTP mixture resulted in significant differences between groups related to sleep patterns (40%, p<0.017) and significantly induced subjective nighttime sleep in the awake model (p<0.003). These results related to transcript levels of the GABAB receptor (GABAB-R1) and serotonin receptor (5-HT1A), compared to the control group. In addition, GABA/5-HTP mixture significantly increased GABA levels 1h and 12h following treatment (2.1 fold and 1.2 fold higher than the control, respectively) and also increased 5-HTP levels (0 h: 1.01 μg/protein, 12h: 3.45 μg/protein).
Significance: In this regard, we successfully demonstrated that using a GABA/5-HTP mixture modulates subjective nighttime activity, sleep episodes, and total duration of subjective nighttime sleep to a greater extent than single administration of each amino acid, and that this modulation occurs via GABAergic and serotonergic signaling.