Citrus Bioflavonoids represent a large number of natural plant polyphenols derived from the rinds and peels of citrus fruits such as grapefruit and oranges. Popular bioflavonoids include compounds such as quercetin, hesperidin, and rutin.
✓ Collagen production
✓ Strengthen elasticity
✓ Improve skin strength
How it works:
Bioflavonoids have synergistic relationships with Vitamin C and have been shown to be powerful antioxidants that promote a healthy inflammation response during aging. Recent research has shown that flavonoids and polyphenols fight harmful free radicals and inhibit advanced glycation end product (AGE) formation, which supports longevity and cognition. Other studies have shown that flavonoids such as quercetin and rutin, can replenish aging cells, promoting elasticity and longevity of healthy skin.
Safe and Effective Dosage:
Clinical studies support safe, effective dosages between 50 mg to over 500 mg per day.
RESEARCH &CLINICAL STUDIES
"Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid"
Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables.
The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer.
These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels.
Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer’s, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress.
Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits.
It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
"Anti-ageing and rejuvenating effects of quercetin"
Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis.
The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins.
Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence.
Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology longer in human primary fibroblasts.
Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts.
Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed.
Finally, we show that these compounds promote physiological alterations when applied to cells (i.e. whitening effect).
In summary, these data demonstrate the existence of naturally occurring anti-ageing products that can be effectively used through topical application.